Research

Principal Investigators affiliated with the CTO program:

 

Dept

 

Principal Investigator

 

Research Area

 

 

 

 

 

Surgery

 

Borel-Rinkes, I.H.M.

 

The responses in the human body to surgery that stimulate tumor growth or the formation of metastases.

 

 

 

 

 

 

 

Hillegersberg van, Richard

 

Malignant diseases of the upper gastrointestinal tract.

 

 

 

 

 

 

 

Grevenstein van, Helma

 

Laparoscopic gastro-intestinal and oncological surgery (including robotsurgery).

 

 

 

 

 

 

 

Kranenburg, Onno

 

Metastatic colon cancer.

 

 

 

 

 

 

 

Molenaar, Quintus

 

Pancreas and liver surgery.

 

 

 

 

 

 

 

Ruurda, Jelle

 

Clinical aspects of operations on esophagus and stomach.

   

 

 

 

 

 

Valk, G.D.

 

M.E.N.-syndrome, pituitary gland disorders, Addison’s disease and endocrine autoimmune diseases.

 

 

 

 

 

 

 

Vriens, Menno

 

Multiple endocrine neoplasia (MEN), thyroid cancer and pancreatic cancer.

 

 

 

 

 

 

 

Witkamp, A.J.

 

Hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancy.

 

 

 

 

 

Head and Neck Surgical Oncology   Van Es, R.J.J.  

Individualized treatment and personalized Head Neck cancer care based on Image-guided and Molecular-guided treatment.

         

Pathology

 

Bovenschen, Niels

 

How do the granzymes normally kill tumor cells and how can tumor cells escape from the cytotoxic immune response.

         
   

Brosens, Lodewijk

  The genetics of cystic preneoplastic pancreatic tumors (IPMN) and the transition to pancreatic carcinoma.

 

 

 

 

 

 

 

Derksen, Patrick

 

How does loss of cell-cell adhesion lead to tumour progression, with an emphasis on breast cancer.

 

 

 

 

 

 

 

Diest van, P.

 

Unraveling the origin of breast cancer optimalization of the diagnostics and treatment of breast cancer.

 

 

 

 

 

 

 

Lacle, Miangela M.

 

Identification of behavior in early invasive colorectal cancer.

 

 

 

 

 

 

 

Leng de, W.W.J.

 

Polyposis and tumorigenesis in Peutz-Jeghers Syndrome.

 

 

 

 

 

 

 

Linn, Sabine

 

1) Understanding the molecular mechanisms underlying differential anti-cancer drug sensitivity in breast and ovarian cancer patients in order to develop tests that may guide treatment decisions in the clinic and ultimately improve survival.


2) Impact of prognostic molecular classifiers on adjuvant systemic treatment advice in breast cancer.

 

 

 

 

 

 

 

Moelans, C.B.

 

Unraveling the genesis of breast cancer and to optimize the diagnostics and treatment of this disease.

 

 

 

 

 

 

 

Offerhaus, Johan

 

Unraveling the molecular and genetic mutations that cause cancer in the digestive tract.

 

 

 

 

 

 

 

Willems, Stefan

 

Molecular Pathology of head and neck carcinoma.

 

 

 

 

 

MDL

 

Baal van, Jantine

 

Molecular mechanism in the development of Barrett's oesophagus and oesophageal adenocarcinoma.

 

 

 

 

 

 

 

Erpecum van, Karel

 

Loco-regional treatment of liver malignancies.

 

 

 

 

 

 

 

Fidder, H.

 

 

 

 

 

 

 

 

 

Linde ter, Jose

 

Chemoprevention, early detection, and correct diagnosis of colorectal adenomas and cancer.

 

 

 

 

 

 

 

Moons, L.M.G.

 

 Detection and endoscopic treatment of early colorectal cancer.

 

 

 

 

 

 

 

Oldenburg, Bas

 

Understanding Crohn’s disease and colitis ulcerosa to offer patients better treatment and a better quality of life.

 

 

 

 

 

 

 

Vleggaar, Frank

 

Clinical trials studying new therapeutic endoscopic procedures (i.e. endo-ultrasound pain blockade and transmural drainages, endoscopic (sub)mucosal resections of early gastro-intestinal cancers in the digestive tract and palliative stent placements).

 

 

 

 

 

Gynaecology

 

Fauser, B.C.J.M.

 

Ovarian function.

 

 

 

 

 

 

 

Verheijen, R.H.M.

 

Micro-metastases, especially in cervical cancer and oncogenesis of ovarian cancer.

 

 

 

 

 

 

 

Zweemer, Ronald

 

Ovarian cancer, (micro)-metastases in cervical cancer and minimal invasive surgery within gynaecological oncology.

 

 

 

 

 

Radio-therapy

 

Gilhuijs, Kenneth

 

Translational imaging in breast oncology: decision support systems for patient tailored therapy selection.

 

 

 

 

 

 

 

Raaymakers, B.

 

Thermal modelling for hyperthermia.

 

 

 

 

 

 

 

Vulpen van, Marco

 

Image-guided radiation therapy.

 

 

 

 

 

 

Radiology

 

Bosch van den, M.

 

Image-guided treatment of cancer (oncological interventions).

 

 

 

 

 

 

 

Lam, Marnix

 

Individualized treatment in nuclear oncology and personalized cancer care based on image-guided treatment.

 

 

 

 

 

Veterinary

Medicine

 

Bruin de, Alain

 

Unraveling the mystery of polyploidy in the liver and to discover the mechanism of tumor suppression by atypical E2Fs.

 

 

 

 

 

 

 

Mol, Jan

 

Spontaneous cancer in companion animals with special interest in cancer stem cells in mammary cancer, adrenocortical tumors and insulinomas of the dog.

 

 

 

 

 

Medical Oncology

 

Langenberg, Marlies

en

Witteveen, Els

 

Phase 1 and 2 studies in cancer patients with solid tumors to explore the safety and tolerance, and sometimes preliminary efficacy of a new medicine.

An overview of recent studies

 

 

 

 

 

 

 

Koopman, Miriam

 

Colorectal cancer: Phase 3 CAIRO studies of the Dutch Colorectal Cancer Group (DCCG) and observational cohort studies (PICNIC).

 

Websites:

link

link

 

 

 

 

 

 

 

Vos de, Filip

 

Primary brain tumors.

 

 

 

 

 

 

 

Wall van der, Elsken

 

Elucidating cellular and angiogenetic pathways that result in breast cancer (development).

 

 

 

 

 

Julius Center

 

Elias, Sjoerd

 

Epidemiological studies of breast cancer.

 

 

 

 

 

 

 

Gils van, Carla

 

The additional value of MRI for women with extremely dense breasts in the population-based breast cancer screening program in the Netherlands.

 

 

 

 

 

 

 

May, Anna

 

Physical activity, obesity and cancer.

 

 

 

 

 

 

 

Onland, Charlotte

 

Molecular end genetic epidemiology of breast- and ovarian cancer.

 

 

 

 

 

 

 

Peeters, Petra

 

Risk assessment and prevention of cancer with a focus on nutrition, lifestyle, biomarkers and genes.

 

Websites:

link

link

 

 

 

 

 

Neuro-Oncology

 

Broekman, Marike

 

Brain tumors with the focus on extracellular vesicles.

 

 

 

 

 

 

 

Robe, Pierre

 

Resistance mechanisms that are activated in tumor cells as a reaction to therapy.

 

 

 

 

 

Clinical Chemistry & Haematology

 

Schiffelers, Raymond

 

Synthetic and natural nanoparticles (~100 nm) for therapy and diagnosis.

 

 

 

 

 

Translational Immunology

 

Nierkens, Stefan

 

Immunomonitoring and immunotherapy.

 

Websites:

link

link

 

Movies:

link

link

 

 

 

 

 

Molecular Cancer Research

 

Lens, Susanne

 

Unraveling the molecular principles that ensure faithful chromosome segregation during cell division, to understand how and why the fidelity of this segregation process is disturbed in cancer cells.

 

 

 

 

 

UPCOMING

CTO PhD Retreat: 10 November 2017

Evaluation last retreat:

4.33 out of 5

Quotes:

"Especially for being new in the group this was a fun introduction!"

"Nice to meet fellow PhD's"

"Morning presentations and fun in the afternoon"

 

Clinical Trial Development Course: 29-30 November and 1 December 2017

Evaluation last course:

4.13 out of 5

Quotes:

"Great way to learn!"

"Gave new insights"

"Inspiring speakers, useful presentations"

"Great course, good organisation"

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