Research
Principal Investigators affiliated with the CTO program:
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Principal Investigator |
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Research Area |
Surgery |
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The responses in the human body to surgery that stimulate tumor growth or the formation of metastases. |
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Malignant diseases of the upper gastrointestinal tract. |
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Laparoscopic gastro-intestinal and oncological surgery (including robotsurgery). |
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Metastatic colon cancer. |
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Pancreas and liver surgery. |
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Clinical aspects of operations on esophagus and stomach. |
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M.E.N.-syndrome, pituitary gland disorders, Addison’s disease and endocrine autoimmune diseases. |
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Multiple endocrine neoplasia (MEN), thyroid cancer and pancreatic cancer. |
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Hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancy. |
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Head and Neck Surgical Oncology | Van Es, R.J.J. |
Individualized treatment and personalized Head Neck cancer care based on Image-guided and Molecular-guided treatment. |
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Pathology |
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How do the granzymes normally kill tumor cells and how can tumor cells escape from the cytotoxic immune response. |
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The genetics of cystic preneoplastic pancreatic tumors (IPMN) and the transition to pancreatic carcinoma. | ||||
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How does loss of cell-cell adhesion lead to tumour progression, with an emphasis on breast cancer. |
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Unraveling the origin of breast cancer optimalization of the diagnostics and treatment of breast cancer. |
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Identification of behavior in early invasive colorectal cancer. |
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Leng de, W.W.J. |
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Polyposis and tumorigenesis in Peutz-Jeghers Syndrome. |
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1) Understanding the molecular mechanisms underlying differential anti-cancer drug sensitivity in breast and ovarian cancer patients in order to develop tests that may guide treatment decisions in the clinic and ultimately improve survival.
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Unraveling the genesis of breast cancer and to optimize the diagnostics and treatment of this disease. |
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Unraveling the molecular and genetic mutations that cause cancer in the digestive tract. |
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Molecular Pathology of head and neck carcinoma. |
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MDL |
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Loco-regional treatment of liver malignancies. |
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Linde ter, Jose |
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Chemoprevention, early detection, and correct diagnosis of colorectal adenomas and cancer. |
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Detection and endoscopic treatment of early colorectal cancer. |
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Understanding Crohn’s disease and colitis ulcerosa to offer patients better treatment and a better quality of life. |
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Clinical trials studying new therapeutic endoscopic procedures (i.e. endo-ultrasound pain blockade and transmural drainages, endoscopic (sub)mucosal resections of early gastro-intestinal cancers in the digestive tract and palliative stent placements). | |
Gynaecology |
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Ovarian function. |
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Ovarian cancer, (micro)-metastases in cervical cancer and minimal invasive surgery within gynaecological oncology. |
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Radio-therapy |
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Translational imaging in breast oncology: decision support systems for patient tailored therapy selection. |
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Thermal modelling for hyperthermia. |
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Radiology |
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Image-guided treatment of cancer (oncological interventions). |
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Individualized treatment in nuclear oncology and personalized cancer care based on image-guided treatment. |
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Veterinary Medicine |
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Unraveling the mystery of polyploidy in the liver and to discover the mechanism of tumor suppression by atypical E2Fs. |
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Spontaneous cancer in companion animals with special interest in cancer stem cells in mammary cancer, adrenocortical tumors and insulinomas of the dog. |
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Medical Oncology |
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Langenberg, Marlies en |
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Phase 1 and 2 studies in cancer patients with solid tumors to explore the safety and tolerance, and sometimes preliminary efficacy of a new medicine. |
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Colorectal cancer: Phase 3 CAIRO studies of the Dutch Colorectal Cancer Group (DCCG) and observational cohort studies (PICNIC).
Websites: |
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Primary brain tumors. |
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Elucidating cellular and angiogenetic pathways that result in breast cancer (development). |
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Julius Center |
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Epidemiological studies of breast cancer. |
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The additional value of MRI for women with extremely dense breasts in the population-based breast cancer screening program in the Netherlands. |
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Physical activity, obesity and cancer. |
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Molecular end genetic epidemiology of breast- and ovarian cancer. |
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Risk assessment and prevention of cancer with a focus on nutrition, lifestyle, biomarkers and genes.
Websites: |
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Neuro-Oncology |
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Brain tumors with the focus on extracellular vesicles. |
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Resistance mechanisms that are activated in tumor cells as a reaction to therapy. |
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Clinical Chemistry & Haematology |
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Synthetic and natural nanoparticles (~100 nm) for therapy and diagnosis. |
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Translational Immunology |
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Immunomonitoring and immunotherapy.
Websites:
Movies: |
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Molecular Cancer Research |
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Unraveling the molecular principles that ensure faithful chromosome segregation during cell division, to understand how and why the fidelity of this segregation process is disturbed in cancer cells. |
Upcoming
PhD Retreat, only for CTO PhD students!
13 May 2022
Quotes PhD retreat 2020:
"The students are a remarkable bunch. They are intelligent and competent, grounded, and considerate of each other"
"Useful, interactive and a boost for the ‘research appetite’"
"I did not expected much of it, but I really had a blast with my peers. Great social boost for me"
Clinical Trial and Development Course
29-30-31 Mach 2022
Quotes Clinical Trial and Development Course 2019:
"Good overview with relevant examples of current trials"
"Useful and interesting course. Both regarding trials (METC, design, etc.) and regarding oncology. Enthusiastic and inspiring speakers!"
"Good balance on theoretical and practical aspects of performing trials"
"Interesting and experienced speakers, who knew how to get their message across"